Reproductive and Cytogenetic Toxicity of Metronidazole in Male Mice

Study on The Reproductive Organs and Fertility of The Male Mice following Administration of Metronidazole

Changes in Reproductive Hormones Secretion Involved in Quantum Dots-induced Reproductive Toxicity in Adult Male Mice

Background and Aims: Quantum dots (QDs), as colloidal nanocrystalline semiconductors, present QD wavelengths in terms of biomedical assays and imaging, though the high toxicity of their core demands to be taken into consideration. Investigating this subject is taken into account as an important concept   concerning use of these nanoparticles in the medical applications. Materials a...

cytogenetic alterations in preimplantation mice embryos following male mouse gonadal gamma-irradiation: comparison of two methods for reproductive toxicity screening

background: genome instability is a main cause of chromosomal alterations in both somatic and germ cells when exposed to environmental, physical and chemical genotoxicants. germ cells especially spermatozoa are more vulnerable to suffering from dna damaging agents during spermatogenesis and also more potent in transmitting genome instability to next generation. methods: to investigate the effec...

Cytogenetic Alterations in Preimplantation Mice Embryos Following Male Mouse Gonadal Gamma-irradiation: Comparison of Two Methods for Reproductive Toxicity Screening

BACKGROUND Genome instability is a main cause of chromosomal alterations in both somatic and germ cells when exposed to environmental, physical and chemical genotoxicants. Germ cells especially spermatozoa are more vulnerable to suffering from DNA damaging agents during spermatogenesis and also more potent in transmitting genome instability to next generation. METHODS To investigate the effec...

Comparison of Toxicity of CdSe: ZnS Quantum Dots on Male Reproductive System in Different Stages of Development in Mice

Background Quantum dots (QDs) are new types of fluorescent materials for biological labeling. QDs toxicity study is an essential requirement for future clinical applications. Therefore, this study aimed to evaluate cytotoxic effects of CdSe: ZnS QDs on male reproductive system. MaterialsAndMethods In this experimental study, the different concentrations of CdSe: ZnS QDs (10, 20 and 40 mg/kg) we...